Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | RORC | P51449 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RORA | P35398 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12465947 | 0.87 | KMT2A (0.47) | HPGDPTGS2RORCGAAPSIP1 | |
| SCHEMBL2655181 | 0.83 | AKR1C3 (0.47) | HPGDPTGS2MT-CO2PTGS1KMT2A | |
| SCHEMBL166813 | 0.81 | PTGS2 (0.53) | PTGS2GAAMT-CO2PSIP1PTGS1 | |
| SCHEMBL23174361 | 0.81 | ESR1 (0.45) | MMP1MMP13RORCGAAPSIP1 | |
| SCHEMBL23174343 | 0.80 | ESR1 (0.44) | MMP1MMP13RORCGAAPSIP1 | |
| SCHEMBL16879899 | 0.79 | EPHX1 (0.54) | RORCGAAPSIP1RORACA12 | |
| SCHEMBL17716834 | 0.78 | ALDH1A1 (0.43) | HPGDMMP1MMP13RORCGAA | |
| SCHEMBL2601861 | 0.77 | CXCR1 (0.49) | HPGDPTGS2PTGS1 | |
| SCHEMBL11130803 | 0.76 | HPGD (0.53) | HPGDPTGS2MT-CO2PTGS1KMT2A | |
| SCHEMBL12896284 | 0.76 | HPGD (0.53) | HPGDPTGS2MT-CO2PTGS1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013029338-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012028100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |