Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.62 |
| ▸ | BCHE | P06276 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5392678 | 0.84 | CETP (0.50) | DNM1BCHECTSD | |
| SCHEMBL7288681 | 0.83 | DNM1 (0.58) | DNM1BCHEMEN1KMT2ACHRM2 | |
| SCHEMBL2924382 | 0.82 | DNM1 (0.62) | DNM1BCHEMEN1KMT2ACHRM2 | |
| SCHEMBL7288676 | 0.82 | DNM1 (0.57) | DNM1BCHEL3MBTL1MEN1KMT2A | |
| SCHEMBL6694692 | 0.81 | DNM1 (0.54) | DNM1BCHEMEN1KMT2AALDH1A1 | |
| SCHEMBL5219603 | 0.81 | DNM1 (0.54) | DNM1BCHEMEN1KMT2AALDH1A1 | |
| SCHEMBL21740355 | 0.81 | DNM1 (0.61) | DNM1BCHEMEN1KMT2ACHRM2 | |
| SCHEMBL27614960 | 0.80 | DNM1 (0.60) | DNM1BCHEMEN1KMT2ACHRM2 | |
| SCHEMBL27646012 | 0.79 | DNM1 (0.58) | DNM1BCHEMEN1KMT2ACHRM2 | |
| SCHEMBL8880839 | 0.78 | KDM4E (0.77) | BCHEMEN1KMT2ACHRM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |