Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10086785 | 0.89 | CASR (0.46) | EPHB3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1684347 | 0.88 | RAB9A (0.50) | EPHB3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10086803 | 0.86 | NPC1 (0.56) | EPHB3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1682619 | 0.83 | EPHB3 (0.46) | EPHB3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10086778 | 0.81 | EPHB3 (0.45) | EPHB3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1683591 | 0.77 | KDM4E (0.50) | EPHB3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29843826 | 0.76 | EPHB3 (0.56) | EPHB3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10086801 | 0.76 | KDM4E (0.52) | EPHB3KDM4ETRPV1NPC1RAB9A | |
| SCHEMBL19362092 | 0.75 | EPHB3 (0.55) | EPHB3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10086784 | 0.75 | EPHB3 (0.57) | EPHB3KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045729-A1 | IMIDAZO [1, 2 -A] PYRIDINE AND PYRAZOLO [1, 5 -A] PYRIDINE DERIVATIVES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-04-12 | — | — | WO | disclosed |