Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 5/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | FES | P07332 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27541332 | 0.93 | KDR (0.51) | KDRPDGFRBEGFRERBB2LCK | |
| SCHEMBL1683450 | 0.87 | KDR (0.67) | KDRPDGFRBEGFRERBB2LCK | |
| SCHEMBL1683433 | 0.81 | KDR (0.76) | KDRPDGFRBEGFRERBB2LCK | |
| SCHEMBL1683443 | 0.71 | KDR (0.61) | KDRPDGFRBEGFRERBB2LCK | |
| SCHEMBL5740525 | 0.68 | KDR (0.44) | KDREGFRFLT4 | |
| SCHEMBL12808319 | 0.67 | KDR (1.00) | KDRPDGFRBEGFRERBB2LCK | |
| SCHEMBL1683398 | 0.67 | KDR (1.00) | KDRPDGFRBEGFRERBB2LCK | |
| SCHEMBL1683431 | 0.67 | KDR (1.00) | KDRPDGFRBEGFRERBB2LCK | |
| SCHEMBL1683459 | 0.67 | KDR (0.84) | KDRPDGFRBEGFRERBB2LCK | |
| SCHEMBL1683464 | 0.67 | KDR (0.84) | KDRPDGFRBEGFRERBB2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539763-B1 | AZAINDOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-04-13 | — | — | EP | claimed |