Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.84 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1683459 | 1.00 | KDR (0.84) | KDRFGFR1EGFRERBB2LCK | |
| SCHEMBL12808319 | 0.91 | KDR (1.00) | KDRFGFR1EGFRERBB2LCK | |
| SCHEMBL1683398 | 0.91 | KDR (1.00) | KDRFGFR1EGFRERBB2LCK | |
| SCHEMBL1683433 | 0.85 | KDR (0.76) | KDRFGFR1EGFRERBB2LCK | |
| SCHEMBL1683431 | 0.81 | KDR (1.00) | KDRFGFR1EGFRERBB2LCK | |
| SCHEMBL26928560 | 0.73 | KDR (1.00) | KDRFGFR1EGFRERBB2LCK | |
| SCHEMBL1683428 | 0.67 | KDR (0.51) | KDRFGFR1EGFRERBB2LCK | |
| SCHEMBL1683443 | 0.67 | KDR (0.61) | KDRFGFR1EGFRERBB2LCK | |
| SCHEMBL1683463 | 0.67 | KDR (0.82) | KDRFGFR1EGFRLCKPDGFRB | |
| SCHEMBL1683465 | 0.67 | KDR (0.82) | KDRFGFR1EGFRLCKPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539763-B1 | AZAINDOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-04-13 | — | — | EP | claimed |
| EP-1539763-B1 | AZAINDOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-04-13 | — | — | EP | disclosed |