Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 6/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.45 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 6/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16822075 | 1.00 | PRKCQ (0.45) | PRKCQPRKCDMAT2AULK1KDR | |
| SCHEMBL16835307 | 1.00 | PRKCQ (0.45) | PRKCQPRKCDMAT2AULK1KDR | |
| SCHEMBL28115998 | 0.79 | PRKCQ (0.44) | PRKCQPRKCDMAT2AULK1KDR | |
| SCHEMBL16821995 | 0.79 | PRKCQ (0.44) | PRKCQPRKCDMAT2AULK1KDR | |
| SCHEMBL16822136 | 0.79 | PRKCQ (0.44) | PRKCQPRKCDMAT2AULK1KDR | |
| SCHEMBL16822089 | 0.79 | PRKCQ (0.52) | PRKCQPRKCDMAT2AMERTK | |
| SCHEMBL16822124 | 0.79 | PRKCQ (0.52) | PRKCQPRKCDMAT2AMERTK | |
| SCHEMBL28115997 | 0.77 | PRKCQ (0.44) | PRKCQPRKCDMAT2AULK1KDR | |
| SCHEMBL25201215 | 0.74 | ULK1 (0.47) | ULK1FLT3ULK2KIT | |
| SCHEMBL16846056 | 0.73 | PRKCQ (0.80) | PRKCQPRKCDPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082819-A1 | SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, LLC (US) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015095679-A1 | SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2015-06-25 | — | — | WO | disclosed |