Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 18/20 | 0.47 |
| ▸ | ULK2 | Q8IYT8 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22998017 | 0.79 | ULK1 (0.50) | ULK1ULK2CYP1A2LRRK2 | |
| SCHEMBL29315926 | 0.79 | ULK1 (0.50) | ULK1ULK2KITFLT3 | |
| SCHEMBL25236867 | 0.79 | ULK1 (0.42) | ULK1ULK2KITFLT3 | |
| SCHEMBL30396187 | 0.79 | ULK1 (0.42) | ULK1ULK2KITFLT3 | |
| SCHEMBL26110421 | 0.77 | MERTK (0.38) | CYP1A2 | |
| SCHEMBL31357116 | 0.77 | MERTK (0.38) | CYP1A2 | |
| SCHEMBL25207209 | 0.76 | LRRK2 (0.34) | CYP1A2LRRK2 | |
| SCHEMBL16835308 | 0.74 | PRKCQ (0.45) | ULK1ULK2KITFLT3 | |
| SCHEMBL16835307 | 0.74 | PRKCQ (0.45) | ULK1ULK2KITFLT3 | |
| SCHEMBL16822075 | 0.74 | PRKCQ (0.45) | ULK1ULK2KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |