Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 12/20 | 0.77 |
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.77 |
| ▸ | OPRK1 known ✓ | P41145 | 8/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.77 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrocodeine SCHEMBL16105089 | 1.00 | OPRD1 (0.77) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 | |
| Hydrocodone SCHEMBL18230599 | 0.96 | OPRM1 (0.83) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 | |
| Hydromorphone SCHEMBL18230602 | 0.94 | OPRD1 (0.84) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 | |
| Hydrocodone SCHEMBL1360903 | 0.93 | OPRM1 (0.89) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 | |
| Dihydrocodeine SCHEMBL20788663 | 0.91 | OPRD1 (0.70) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 | |
| Codeine SCHEMBL3239478 | 0.88 | OPRM1 (0.72) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 | |
| Codeine SCHEMBL250022 | 0.88 | OPRM1 (0.72) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 | |
| Hydrocodone SCHEMBL12013631 | 0.88 | OPRD1 (1.00) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 | |
| Hydrocodone SCHEMBL12402839 | 0.88 | OPRD1 (1.00) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 | |
| Hydrocodone SCHEMBL21335350 | 0.88 | OPRD1 (1.00) | OPRD1OPRM1OPRK1PDE4DMRGPRX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098284-A1 | Methods and compositions for treating pain | THERAQUEST BIOSCIENCES, LLC | 2011-04-28 | — | — | US | disclosed |
| WO-2008150324-A1 | SUBANALGESIC DOSES OF DRUG COMBINATIONS | THERAQUEST BIOSCIENCES, INC. (US) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008115572-A1 | METHODS AND COMPOSITIONS OF NSAIDS | THERAQUEST BIOSCIENCES, INC. (US) | 2008-09-25 | — | — | WO | disclosed |
| EP-1893190-A2 | METHODS AND COMPOSITIONS FOR TREATING PAIN | Theraquest Biosciences, LLC (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006116626-A2 | METHODS AND COMPOSITIONS FOR TREATING PAIN | THERAQUEST BIOSCIENCES LLC (US) | 2006-11-02 | — | — | WO | disclosed |