Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896094 | 0.78 | CDC7 (0.47) | CDC7CDK2SLC22A12MKNK2RAPGEF4 | |
| SCHEMBL6646174 | 0.64 | CDC7 (0.45) | CDC7CDK2SLC22A12MKNK2RAPGEF4 | |
| SCHEMBL27976818 | 0.64 | CDC7 (0.45) | CDC7CDK2SLC22A12MKNK2RAPGEF4 | |
| SCHEMBL18940537 | 0.64 | CDC7 (0.45) | CDC7CDK2SLC22A12MKNK2RAPGEF4 | |
| SCHEMBL30267535 | 0.64 | CDC7 (0.45) | CDC7CDK2SLC22A12MKNK2RAPGEF4 | |
| SCHEMBL29497360 | 0.64 | MAPT (0.50) | CDC7CDK2SLC22A12MKNK2RAPGEF4 | |
| SCHEMBL10197254 | 0.64 | CDC7 (0.45) | CDC7CDK2SLC22A12MKNK2RAPGEF4 | |
| SCHEMBL14312995 | 0.64 | CDC7 (0.49) | CDC7CDK2SLC22A12MKNK2RAPGEF4 | |
| SCHEMBL256341 | 0.64 | MAPT (0.50) | CDC7CDK2SLC22A12MKNK2RAPGEF4 | |
| SCHEMBL26707698 | 0.62 | AOC3 (0.41) | CDC7CDK2SLC22A12MKNK2RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083618-A1 | NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-C]PYRIDAZINES AS LRRK2 INHIBITORS | Pfizer Inc. (US) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015092592-A1 | NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-C]PYRIDAZINES AS LRRK2 INHIBITORS | PFIZER INC. (US) | 2015-06-25 | — | — | WO | disclosed |