SCHEMBL16838271

SCHEMBL16838271

Cc1cnc(C2CC2)nc1Cl

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 19/20 0.55
PIK3C3 Q8NEB9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19302651 0.79 PDE10A (0.39) PDE10APIK3C3
SCHEMBL3017328 0.79 PDE10A (0.48) PDE10A
SCHEMBL11377088 0.76 PDE10A (0.36) PDE10APIK3C3
SCHEMBL28793330 0.76 PDE10A (0.47) PDE10APIK3C3
SCHEMBL30829012 0.76 PDE10A (0.46) PDE10A
SCHEMBL3826088 0.74 PDE10A (0.39) PDE10A
SCHEMBL25744956 0.73 PDE10A (0.38) PDE10APIK3C3
SCHEMBL10413068 0.72 PDE10A (0.36) PDE10APIK3C3
SCHEMBL7948803 0.72 PDE10A (0.41) PDE10A
SCHEMBL30283284 0.72 PDE10A (0.41) PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9062056-B2 Aza-benzimidazolone Chymase inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-06-23 US disclosed