Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLL | Q9UGP5 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583999 | 0.89 | KDM4E (0.52) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL6272000 | 0.82 | CYP1A2 (0.39) | POLLALDH1A1ACHEHSD17B10MAPT | |
| SCHEMBL16835942 | 0.78 | KDM4E (0.43) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL30618055 | 0.78 | KDM4E (0.55) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL8616972 | 0.78 | KDM4E (0.55) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL2722920 | 0.72 | ADRA1A (0.52) | POLLKDM4EALDH1A1HPGDGLA | |
| SCHEMBL11985670 | 0.72 | RXRG (0.34) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1024516 | 0.71 | CES1 (0.36) | ALDH1A1HPGDHTR2AHTR2CHTR2B | |
| SCHEMBL2641069 | 0.71 | DRD2 (0.50) | ACHEHTR2A | |
| SCHEMBL11985669 | 0.71 | KDM4E (0.41) | KDM4EALDH1A1HPGDGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091411-A1 | SPIRO-OXAZOLONES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-25 | — | — | WO | disclosed |