Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 8/20 | 0.53 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.45 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20272988 | 0.86 | SPHK1 (0.51) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL12634418 | 0.86 | SPHK1 (0.51) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL17801791 | 0.86 | SPHK1 (0.51) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL17661962 | 0.85 | LTA4H (0.56) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL17637516 | 0.85 | LTA4H (0.56) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL26266218 | 0.84 | SPHK1 (0.68) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL13258710 | 0.84 | LTA4H (0.62) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL18867987 | 0.84 | SPHK1 (0.49) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL24395095 | 0.83 | SPHK1 (0.57) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL14850430 | 0.83 | SPHK1 (0.57) | SPHK1SPHK2S1PR1S1PR3S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054315-A1 | METHOD OF CONJUGATING A POLYPEPTIDE | MEDIMMUNE, LLC (US) | 2016-04-07 | — | — | WO | disclosed |
| WO-2015095227-A2 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2015-06-25 | — | — | WO | disclosed |