Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19017845 | 0.88 | MAPT (0.49) | MAPTTDP1KDM4EGLAGAA | |
| SCHEMBL16847608 | 0.88 | MAPT (0.49) | MAPTTDP1KDM4EGLAGAA | |
| SCHEMBL17650866 | 0.86 | CA1 (0.50) | MAPTTDP1KDM4EGLAGAA | |
| SCHEMBL16424794 | 0.84 | CA1 (0.47) | MAPTTDP1KDM4EGLAGAA | |
| SCHEMBL12285414 | 0.81 | PSMB8 (0.47) | MAPTTDP1PAX8NPSR1CA1 | |
| SCHEMBL16424793 | 0.78 | MDM2 (0.44) | MAPTTDP1KDM4EGLAGAA | |
| SCHEMBL28074876 | 0.77 | CA1 (0.57) | MAPTTDP1KDM4EGLAGAA | |
| SCHEMBL14378788 | 0.77 | CA1 (0.59) | MAPTTDP1KDM4EGLAGAA | |
| SCHEMBL14950097 | 0.77 | SIRT5 (0.42) | MAPTTDP1KDM4EGLAGAA | |
| SCHEMBL18332009 | 0.77 | CA1 (0.45) | MAPTTDP1KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095227-A2 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2015-06-25 | — | — | WO | disclosed |