Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Levulinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.78 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.50 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | KDM5C | P41229 | 2/20 | 0.50 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.50 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.50 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levulinic Acid SCHEMBL27931545 | 0.88 | LMNA (1.00) | LMNASLC15A2ALDH1A1EGLN1PHF8 | |
| Levulinic Acid SCHEMBL20868 | 0.88 | — | — | |
| Levulinic Acid SCHEMBL30530258 | 0.88 | — | — | |
| Levulinic Acid SCHEMBL113572 | 0.88 | LMNA (1.00) | LMNASLC15A2ALDH1A1EGLN1PHF8 | |
| Levulinic Acid SCHEMBL10791504 | 0.85 | — | — | |
| Levulinic Acid SCHEMBL21815797 | 0.85 | — | — | |
| Levulinic Acid SCHEMBL8063365 | 0.85 | LMNA (0.93) | LMNASLC15A2ALDH1A1EGLN1PHF8 | |
| Levulinic Acid SCHEMBL21815732 | 0.85 | — | — | |
| Levulinic Acid SCHEMBL21815633 | 0.85 | — | — | |
| Levulinic Acid SCHEMBL21815654 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305237-B1 | THERAPEUTIC AGENT FOR MALE STERILITY | SBI PHARMACEUTICALS CO LTD (JP) | 2014-04-30 | — | — | EP | disclosed |
| US-8563605-B2 | Therapeutic agent for male sterility | SBI PHARMACEUTICALS CO., LTD. (JP) | 2013-10-22 | — | — | US | disclosed |
| EP-2305237-A1 | THERAPEUTIC AGENT FOR MALE STERILITY | SBI ALApromo Co., Ltd. (JP) | 2011-04-06 | — | — | EP | disclosed |
| US-20110065787-A1 | THERAPEUTIC AGENT FOR MALE STERILITY | SBI ALApromo., Ltd. | 2011-03-17 | — | — | US | disclosed |