Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 14/20 | 0.59 |
| ▸ | AR | P10275 | 13/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16852316 | 1.00 | PGR (0.59) | PGRARNR3C1CHRM2LMNA | |
| SCHEMBL12568121 | 1.00 | PGR (0.59) | PGRARNR3C1CHRM2LMNA | |
| SCHEMBL16852318 | 1.00 | PGR (0.59) | PGRARNR3C1CHRM2LMNA | |
| SCHEMBL10355962 | 0.85 | PGR (0.51) | PGRARNR3C1CHRM2LMNA | |
| SCHEMBL12568120 | 0.81 | PGR (0.65) | PGRARNR3C1CHRM2LMNA | |
| SCHEMBL16852314 | 0.81 | PGR (0.65) | PGRARNR3C1CHRM2LMNA | |
| SCHEMBL12568118 | 0.80 | PGR (0.58) | PGRARNR3C1CHRM2LMNA | |
| SCHEMBL16852315 | 0.80 | PGR (0.58) | PGRARNR3C1CHRM2LMNA | |
| SCHEMBL10355879 | 0.79 | PGR (0.47) | PGRARNR3C1CHRM2LMNA | |
| SCHEMBL10355849 | 0.77 | PGR (0.39) | PGRARNR3C1CHRM2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265629-B1 | BISMETHYLENE-17 CARBOLACTONES AND RELATED USES | EVESTRA INC (US) | 2015-06-24 | — | — | EP | disclosed |