Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 5/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.39 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 3/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16854504 | 0.90 | GLA (0.45) | GLAHTTNPSR1SMOHRH4 | |
| SCHEMBL18166832 | 0.88 | HRH4 (0.39) | HRH4OGAACACBHRH3 | |
| SCHEMBL16854507 | 0.78 | JAK2 (0.41) | HRH4 | |
| SCHEMBL26819125 | 0.74 | ACHE (0.44) | HRH4OGAACACBHRH3 | |
| SCHEMBL16854413 | 0.71 | CXCR4 (0.37) | SMOHRH4PTPN11OGAHTR6 | |
| SCHEMBL16854416 | 0.70 | TSHR (0.52) | OGA | |
| SCHEMBL16854707 | 0.70 | CXCR4 (0.38) | HRH4OGAACACBHRH3 | |
| SCHEMBL25435536 | 0.69 | MAPK8 (0.36) | — | |
| SCHEMBL26669204 | 0.69 | HRH3 (0.56) | HTTHRH4HTR6HRH3 | |
| SCHEMBL16854503 | 0.69 | MEN1 (0.39) | PDCD1LG2CD274OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3085701-B1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2019-02-20 | — | — | EP | claimed |
| US-10023565-B2 | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-07-17 | — | — | US | claimed |
| US-20160333002-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2016-11-17 | — | — | US | claimed |
| EP-3085701-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2016-10-26 | — | — | EP | claimed |
| CN-105829304-A | N, n substituted piperidinamine compounds, and preparation method and usage thereof | 中国人民解放军军事医学科学院毒物药物研究所 | 2016-08-03 | — | — | CN | claimed |
| EP-3085701-B1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2019-02-20 | — | — | EP | disclosed |
| EP-3085701-B1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2019-02-20 | — | — | EP | disclosed |
| US-10023565-B2 | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-07-17 | — | — | US | disclosed |
| US-10023565-B2 | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-07-17 | — | — | US | disclosed |
| US-10023565-B2 | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-07-17 | — | — | US | disclosed |
| US-20160333002-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2016-11-17 | — | — | US | disclosed |
| US-20160333002-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2016-11-17 | — | — | US | disclosed |
| US-20160333002-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2016-11-17 | — | — | US | disclosed |
| EP-3085701-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2016-10-26 | — | — | EP | disclosed |
| CN-105829304-A | N, n substituted piperidinamine compounds, and preparation method and usage thereof | 中国人民解放军军事医学科学院毒物药物研究所 | 2016-08-03 | — | — | CN | disclosed |
| WO-2015090226-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | 中国人民解放军军事医学科学院毒物药物研究所 | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023565-B2 | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof | HSP90AB1, HSP90AB2P, HSF1 | GLA 4679/4885HTT 31/4885NPSR1 106/4885 |
| US-20160333002-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | HSP90AB1, HSP90AB2P, HSF1 | GLA 4679/4885HTT 31/4885NPSR1 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.