SCHEMBL16855020

SCHEMBL16855020

O=CN1C[C@@H](F)C[C@@H]1C(=O)O

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.33
ATM Q13315 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17428805 0.78 KMT2A (0.34) KMT2AATM
SCHEMBL8337707 0.78 ATM (0.50) KMT2AATM
SCHEMBL14365837 0.78 ATM (0.50) KMT2AATM
SCHEMBL11032287 0.76 ATM (0.40) KMT2AATM
SCHEMBL27925973 0.72 ATM (0.35) ATM
SCHEMBL14621725 0.72 KMT2A (0.44) KMT2A
SCHEMBL20839633 0.72 ATM (0.37) ATM
SCHEMBL6917334 0.71 ATM (0.42) ATM
SCHEMBL755185 0.71 ATM (0.38) ATM
SCHEMBL22360773 0.71 ATM (0.38) ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015095477-A1 [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS IRM LLC (BM) 2015-06-25 WO disclosed