Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24195828 | 0.90 | CSF1R (0.39) | HPGDMAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL23850846 | 0.89 | MAP2K1 (0.50) | FLT1MAP2K1 | |
| SCHEMBL31135631 | 0.89 | MAP2K1 (0.50) | FLT1MAP2K1 | |
| SCHEMBL31135636 | 0.88 | MAP2K1 (0.36) | HPGDSMN1; SMN2LMNAALDH1A1MAP2K1 | |
| SCHEMBL1615057 | 0.88 | MAP2K1 (0.36) | HPGDSMN1; SMN2LMNAALDH1A1MAP2K1 | |
| SCHEMBL24196144 | 0.87 | MAP2K1 (0.35) | HPGDALDH1A1MAP2K1GAA | |
| SCHEMBL10546863 | 0.84 | NPC1 (0.45) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL10547265 | 0.82 | FGFR1 (0.44) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL10549450 | 0.82 | NPC1 (0.43) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL22853043 | 0.80 | MAPK3 (0.41) | HPGDNPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2690101-B1 | 5-Anilinoimidazopyridines and Methods of Use | GENENTECH INC (US) | 2015-06-24 | — | — | EP | disclosed |