Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294640 | 1.00 | MAPK3 (0.41) | MAPK3HPGDMAPK13MAPK12MAPK11 | |
| SCHEMBL30294466 | 0.89 | CLCN2 (0.43) | MAPK3HPGDMAPK13MAPK12MAPK11 | |
| SCHEMBL22853078 | 0.89 | CLCN2 (0.43) | MAPK3HPGDMAPK13MAPK12MAPK11 | |
| SCHEMBL30294558 | 0.88 | HPGD (0.42) | MAPK3HPGDALDH1A1LMNAHTT | |
| SCHEMBL30294279 | 0.86 | P2RX7 (0.41) | HPGDALDH1A1NPSR1 | |
| SCHEMBL22853042 | 0.86 | P2RX7 (0.41) | HPGDALDH1A1NPSR1 | |
| SCHEMBL22853360 | 0.85 | MAPK13 (0.45) | MAPK3HPGDMAPK13MAPK12MAPK11 | |
| SCHEMBL22853046 | 0.85 | MAPK13 (0.45) | MAPK3HPGDMAPK13MAPK12MAPK11 | |
| SCHEMBL30294310 | 0.85 | MAPK13 (0.45) | MAPK3HPGDMAPK13MAPK12MAPK11 | |
| SCHEMBL30294532 | 0.85 | MAPK13 (0.45) | MAPK3HPGDMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |