Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | PPARA | Q07869 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19346178 | 0.88 | PPARG (0.48) | PPARGPPARANPC1RAB9AL3MBTL1 | |
| SCHEMBL6583440 | 0.88 | PPARG (0.46) | PPARGPPARANPC1RAB9AL3MBTL1 | |
| SCHEMBL670353 | 0.87 | PPARG (0.47) | PPARGPPARANPC1RAB9AL3MBTL1 | |
| SCHEMBL16963899 | 0.86 | LMNA (0.49) | PPARGPPARANPC1RAB9AL3MBTL1 | |
| SCHEMBL8060935 | 0.86 | SLC7A5 (0.50) | PPARGPPARANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL68412 | 0.84 | L3MBTL1 (0.50) | PPARGPPARANPC1RAB9AL3MBTL1 | |
| SCHEMBL6650515 | 0.81 | AKR1B1 (0.48) | PPARGPPARANFKB1PTGS2ALDH1A1 | |
| SCHEMBL15956080 | 0.81 | NPC1 (0.57) | PPARGPPARANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL406058 | 0.80 | MAOB (0.58) | SMN1; SMN2MAOBALDH1A1MAPK1EPHX2 | |
| SCHEMBL27544720 | 0.79 | F10 (0.43) | PPARGPPARANPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013029338-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012028100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |