Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1683129 | 0.89 | GAA (0.36) | GAABACE1KMT2A | |
| SCHEMBL3814397 | 0.84 | GAA (0.31) | GAA | |
| SCHEMBL1645089 | 0.81 | F2 (0.37) | GAAMEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL3373246 | 0.80 | GAA (0.34) | GAABACE1 | |
| SCHEMBL3814044 | 0.77 | GAA (0.34) | GAABACE1 | |
| SCHEMBL4295086 | 0.74 | ADRB3 (0.31) | GAABACE1 | |
| SCHEMBL4507930 | 0.74 | GAA (0.47) | GAANAAAMEN1ALDH1A1TSHR | |
| SCHEMBL3811327 | 0.73 | GAA (0.33) | GAA | |
| SCHEMBL12343884 | 0.72 | F2 (0.33) | GAABACE1NAAAPLG | |
| SCHEMBL8054841 | 0.72 | MEN1 (0.31) | GAABACE1MEN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305697-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2103623-A2 | Novel macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2009-09-23 | — | — | EP | disclosed |