Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204195 | 1.00 | AURKA (0.47) | AURKARPS6KB1SLC7A5NOS3NOS1 | |
| Trifluoroacetic Acid SCHEMBL29643011 | 0.94 | PDK1 (0.46) | AURKARPS6KB1SLC7A5NOS3NOS1 | |
| SCHEMBL20215005 | 0.90 | AURKA (0.47) | AURKARPS6KB1SLC7A5NOS3NOS1 | |
| SCHEMBL20204198 | 0.88 | AURKA (0.46) | AURKARPS6KB1SLC7A5NOS3NOS1 | |
| SCHEMBL18179951 | 0.88 | AURKA (0.46) | AURKARPS6KB1SLC7A5NOS3NOS1 | |
| SCHEMBL20204187 | 0.85 | CYP17A1 (0.53) | AURKARPS6KB1HDAC1HDAC3HDAC8 | |
| SCHEMBL16856562 | 0.85 | CYP17A1 (0.53) | AURKARPS6KB1HDAC1HDAC3HDAC8 | |
| SCHEMBL3050840 | 0.85 | SLC7A5 (0.64) | AURKARPS6KB1SLC7A5NOS3NOS1 | |
| SCHEMBL2367233 | 0.85 | SLC7A5 (0.64) | AURKARPS6KB1SLC7A5NOS3NOS1 | |
| SCHEMBL2367419 | 0.84 | SLC7A5 (0.50) | AURKARPS6KB1SLC7A5NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240352122-A1 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | NOVARTIS AG (CH) | 2024-10-24 | — | — | US | disclosed |
| US-11999786-B2 | Anti-CD48 antibodies, antibody drug conjugates, and uses thereof | NOVARTIS AG (CH) | 2024-06-04 | — | — | US | disclosed |
| EP-4251648-A2 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | Novartis AG (CH) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022112942-A2 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | NOVARTIS AG (CH) | 2022-06-02 | — | — | WO | disclosed |
| US-20220162308-A1 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | NOVARTIS AG (CH) | 2022-05-26 | — | — | US | disclosed |
| US-20220162308-A1 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | NOVARTIS AG (CH) | 2022-05-26 | — | — | US | disclosed |
| US-20210228731-A1 | ANTIBODY DRUG CONJUGATES FOR ABLATING HEMATOPOIETIC STEM CELLS | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. | 2021-07-29 | — | — | US | disclosed |
| EP-3753578-A1 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | Novartis AG (CH) | 2020-12-23 | — | — | EP | disclosed |
| US-10787480-B2 | Cytotoxic peptides and conjugates thereof | NOVARTIS AG (CH) | 2020-09-29 | — | — | US | disclosed |
| US-10392421-B2 | Cytotoxic peptides and conjugates thereof | NOVARTIS AG (CH) | 2019-08-27 | — | — | US | disclosed |
| US-20190194315-A1 | ANTIBODY DRUG CONJUGATES | NOVARTIS AG (CH) | 2019-06-27 | — | — | US | disclosed |
| CN-106573956-A | Auristatin derivatives and conjugates thereof | 诺华股份有限公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-105899526-A | Cytotoxic peptides and conjugates thereof | 诺华股份有限公司 | 2016-08-24 | — | — | CN | disclosed |
| WO-2015095301-A2 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | IRM LLC (BM) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999786-B2 | Anti-CD48 antibodies, antibody drug conjugates, and uses thereof | ITGB8, ITGA8, CD4 | AURKA 1956/4885RPS6KB1 3097/4885SLC7A5 1560/4885 |
| US-20240352122-A1 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | ITGB8, ITGA8, CD4 | AURKA 1956/4885RPS6KB1 3097/4885SLC7A5 1560/4885 |
| US-10787480-B2 | Cytotoxic peptides and conjugates thereof | CD47, NGLY1, VIP | AURKA 1051/4885RPS6KB1 1951/4885SLC7A5 1264/4885 |
| US-20190194315-A1 | ANTIBODY DRUG CONJUGATES | EPCAM, CDH1, VIM | AURKA 61/4885RPS6KB1 3800/4885SLC7A5 1083/4885 |
| US-10392421-B2 | Cytotoxic peptides and conjugates thereof | CD47, NGLY1, VIP | AURKA 1051/4885RPS6KB1 1951/4885SLC7A5 1264/4885 |
| US-20210228731-A1 | ANTIBODY DRUG CONJUGATES FOR ABLATING HEMATOPOIETIC STEM CELLS | BCR, ABL1, CD47 | AURKA 208/4885RPS6KB1 3679/4885SLC7A5 3020/4885 |
| US-20220162308-A1 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | ITGB8, ITGA8, CD4 | AURKA 1956/4885RPS6KB1 3097/4885SLC7A5 1560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.