Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14363624 | 0.86 | L3MBTL1 (0.47) | L3MBTL1S1PR1NPC1GAARAB9A | |
| SCHEMBL14363635 | 0.83 | L3MBTL1 (0.47) | L3MBTL1S1PR1NPC1GAARAB9A | |
| SCHEMBL16067419 | 0.82 | L3MBTL1 (0.50) | L3MBTL1NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL18195998 | 0.81 | L3MBTL1 (0.42) | L3MBTL1S1PR1OPRK1GABRG2GABRB3 | |
| SCHEMBL20928592 | 0.81 | L3MBTL1 (0.42) | L3MBTL1S1PR1OPRK1GABRG2GABRB3 | |
| SCHEMBL14363613 | 0.80 | NPC1 (0.49) | L3MBTL1NPC1RAB9A | |
| SCHEMBL14580440 | 0.79 | RAB9A (0.49) | L3MBTL1NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL31415432 | 0.79 | L3MBTL1 (0.47) | L3MBTL1NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL493416 | 0.79 | NR1H4 (0.43) | S1PR1NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL20911215 | 0.79 | NPC1 (0.48) | L3MBTL1S1PR1NPC1RAB9ATRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095442-A1 | PIPERIDINYLOXY LACTONE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-06-25 | — | — | WO | disclosed |