Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17583342 | 0.79 | KDM4E (0.57) | GAACYP1A2CYP2C9KDM4ELRRK2 | |
| SCHEMBL30622679 | 0.79 | KDM4E (0.57) | GAACYP1A2CYP2C9KDM4ELRRK2 | |
| SCHEMBL25120594 | 0.77 | KDM4E (0.61) | GAACYP1A2CYP2C9KDM4ELRRK2 | |
| SCHEMBL10076882 | 0.76 | KDM4E (0.47) | GAACYP1A2CYP2C9KDM4ELRRK2 | |
| SCHEMBL26797380 | 0.76 | LRRK2 (0.52) | GAACYP1A2CYP2C9KDM4ELRRK2 | |
| SCHEMBL31271466 | 0.74 | CYP1A2 (0.58) | CYP1A2CYP2C9ALDH1A1LMNAPOLB | |
| SCHEMBL22199155 | 0.74 | CYP1A2 (0.58) | CYP1A2CYP2C9ALDH1A1LMNAPOLB | |
| SCHEMBL21500052 | 0.73 | LRRK2 (0.49) | GAACYP1A2CYP2C9KDM4ELRRK2 | |
| SCHEMBL29445436 | 0.72 | CYP1A2 (0.56) | GAACYP1A2CYP2C9KDM4ELRRK2 | |
| SCHEMBL1551043 | 0.72 | CYP1A2 (0.56) | GAACYP1A2CYP2C9KDM4ELRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150299188-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-10-22 | — | — | US | disclosed |
| EP-2889291-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-07-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299188-A1 | HETEROCYCLIC COMPOUND | PTGIS, LIPG, FEN1 | GAA 861/4885CYP1A2 3534/4885CYP2C9 3766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.