Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3021059 | 0.87 | EGLN1 (0.56) | EGLN1 | |
| SCHEMBL16857781 | 0.86 | EGLN1 (0.55) | PARGEGLN1 | |
| SCHEMBL16857807 | 0.83 | MGLL (0.46) | EGLN1ALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL16857708 | 0.83 | MGLL (0.45) | EGLN1ALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL16857902 | 0.82 | HPGD (0.46) | EGLN1HPGDMGLLSPR | |
| SCHEMBL16857901 | 0.80 | EGLN1 (0.44) | EGLN1SPRKDM4C | |
| SCHEMBL16857877 | 0.80 | EGLN1 (0.47) | EGLN1SPR | |
| SCHEMBL16857888 | 0.80 | EGLN1 (0.52) | EGLN1KDM4E | |
| SCHEMBL16857900 | 0.80 | EGLN1 (0.52) | EGLN1LMNAKDM4EMGLL | |
| SCHEMBL16857839 | 0.80 | EGLN1 (0.52) | EGLN1GAARXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396316-B1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-01 | — | — | EP | claimed |