Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.39 |
| ▸ | TUBB | P07437 | 2/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16857699 | 0.94 | EGLN1 (0.56) | EGLN1KDM4ELMNAHSD17B10BRD4 | |
| SCHEMBL16857828 | 0.93 | EGLN1 (0.50) | EGLN1KDM4ELMNAHSD17B10TUBB4A | |
| SCHEMBL16857855 | 0.92 | EGLN1 (0.48) | EGLN1KDM4ELMNAHSD17B10TUBB4A | |
| SCHEMBL16857775 | 0.92 | EGLN1 (0.49) | EGLN1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL16857798 | 0.90 | EGLN1 (0.49) | EGLN1 | |
| SCHEMBL16857791 | 0.90 | EGLN1 (0.47) | EGLN1CHEK2 | |
| SCHEMBL16857737 | 0.90 | EGLN1 (0.53) | EGLN1KDM4ELMNAHSD17B10 | |
| SCHEMBL16857802 | 0.90 | EGLN1 (0.44) | EGLN1KDM4ELMNAHSD17B10TUBB4A | |
| SCHEMBL16857875 | 0.89 | EGLN1 (0.47) | EGLN1KDM4ELMNAHSD17B10TUBB4A | |
| SCHEMBL16857887 | 0.88 | EGLN1 (0.48) | EGLN1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396316-B1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-01 | — | — | EP | claimed |