SCHEMBL16857764

SCHEMBL16857764

O=C(O)Oc1cnn(-c2nc3cc(F)c(Br)cc3c(=O)[nH]2)c1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 19/20 0.50
MGLL Q99685 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16857813 0.91 EGLN1 (0.49) EGLN1
SCHEMBL16551730 0.86 EGLN1 (0.64) EGLN1
SCHEMBL16857839 0.84 EGLN1 (0.52) EGLN1
SCHEMBL16857766 0.84 EGLN1 (0.52) EGLN1MGLL
SCHEMBL3031374 0.84 EGLN1 (0.71) EGLN1
SCHEMBL16857744 0.83 EGLN1 (0.48) EGLN1MGLL
SCHEMBL16857827 0.83 EGLN1 (0.48) EGLN1MGLL
SCHEMBL16857812 0.83 EGLN1 (0.49) EGLN1
SCHEMBL16857756 0.82 EGLN1 (0.53) EGLN1
SCHEMBL16857761 0.82 SPR (0.39) EGLN1MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2396316-B1 QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2015-07-01 EP claimed