Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16857707 | 0.90 | ITGB3 (0.49) | BRD4EGLN1ITGB3ITGA2BMAPT | |
| SCHEMBL16857842 | 0.88 | EGLN1 (0.46) | BRD4EGLN1ITGB3ITGA2BMAPT | |
| SCHEMBL16857750 | 0.86 | IP6K1 (0.47) | EGLN1ITGB3ITGA2B | |
| SCHEMBL3026972 | 0.85 | EGLN1 (0.63) | EGLN1 | |
| SCHEMBL16857806 | 0.84 | EGLN1 (0.49) | BRD4EGLN1ITGB3ITGA2BMAPT | |
| SCHEMBL16857820 | 0.84 | EGLN1 (0.46) | EGLN1ITGB3ITGA2B | |
| SCHEMBL16857767 | 0.84 | BRD4 (0.47) | BRD4EGLN1KDRALDH1A1 | |
| SCHEMBL16857757 | 0.84 | EGLN1 (0.44) | EGLN1ITGB3ITGA2BMAPTNPC1 | |
| SCHEMBL16857786 | 0.83 | EGLN1 (0.57) | EGLN1 | |
| SCHEMBL16857880 | 0.83 | EGLN1 (0.44) | EGLN1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396316-B1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-01 | — | — | EP | claimed |