Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | ATIC | P31939 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 6/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16857880 | 0.88 | EGLN1 (0.44) | EGLN1MET | |
| SCHEMBL3035606 | 0.86 | KEAP1 (0.62) | EGLN1KEAP1NFE2L2 | |
| SCHEMBL16857785 | 0.84 | BRD4 (0.47) | BRD4EGLN1KDRALDH1A1 | |
| SCHEMBL16857707 | 0.83 | ITGB3 (0.49) | BRD4EGLN1SMN1; SMN2 | |
| SCHEMBL16857750 | 0.83 | IP6K1 (0.47) | EGLN1 | |
| SCHEMBL16857842 | 0.82 | EGLN1 (0.46) | BRD4EGLN1LMNASMN1; SMN2 | |
| SCHEMBL16857820 | 0.82 | EGLN1 (0.46) | EGLN1 | |
| SCHEMBL16857781 | 0.81 | EGLN1 (0.55) | EGLN1 | |
| SCHEMBL16857786 | 0.81 | EGLN1 (0.57) | EGLN1 | |
| SCHEMBL16857901 | 0.80 | EGLN1 (0.44) | EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396316-B1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-01 | — | — | EP | claimed |