Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686226 | 0.94 | TRPV1 (0.81) | TRPV1KCNH2 | |
| SCHEMBL2790645 | 0.94 | TRPV1 (0.81) | TRPV1KCNH2 | |
| SCHEMBL1686225 | 0.94 | TRPV1 (0.81) | TRPV1KCNH2 | |
| SCHEMBL1686223 | 0.94 | TRPV1 (0.81) | TRPV1KCNH2 | |
| SCHEMBL1686312 | 0.89 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL1686375 | 0.89 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL1686513 | 0.86 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL1686314 | 0.83 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL1686381 | 0.83 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL1686276 | 0.83 | TRPV1 (0.79) | TRPV1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211927-B2 | 5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators | MSD, Oss B.V. (NL) | 2012-07-03 | — | — | US | claimed |
| EP-2185530-B1 | 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | ORGANON NV (NL) | 2011-09-14 | — | — | EP | claimed |
| US-20110065764-A1 | 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. Organon and Pharmacopeia, LLC (NL) | 2011-03-17 | — | — | US | claimed |
| US-8211927-B2 | 5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators | MSD, Oss B.V. (NL) | 2012-07-03 | — | — | US | disclosed |
| US-20110065764-A1 | 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. Organon and Pharmacopeia, LLC (NL) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065764-A1 | 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | TRPV1, TRPV5, TRPV3 | TRPV1 1/4885KCNH2 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.