SCHEMBL1686641

SCHEMBL1686641

O[Si](O)(O)c1cccc2cc3ccccc3cc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.47
KDM4E B2RXH2 4/20 0.47
GAA P10253 3/20 0.47
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HSD17B10 Q99714 3/20 0.41
HIF1A Q16665 1/20 0.41
CYP1B1 Q16678 1/20 0.41
CYP1A2 P05177 5/20 0.39
HPGD P15428 4/20 0.39
GLA P06280 3/20 0.39
CYP2C19 P33261 1/20 0.39
ACHE P22303 2/20 0.38
CYP3A4 P08684 1/20 0.38
ERBB2 P04626 1/20 0.38
FYN P06241 1/20 0.38
MAOA P21397 1/20 0.38
AHR P35869 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29777493 1.00 ALDH1A1 (0.47) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL1686762 0.89 ALDH1A1 (0.46) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL15848643 0.85 ALDH1A1 (0.43) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL15848460 0.82 ALDH1A1 (0.41) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL29777502 0.80 ALDH1A1 (0.41) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL2552874 0.80 ALDH1A1 (0.41) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL14600079 0.80 ALDH1A1 (0.41) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL1053431 0.79 ALDH1A1 (0.47) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL28049648 0.78 ALDH1A1 (0.40) ALDH1A1KDM4EGAAKMT2AMEN1
SCHEMBL27665193 0.78 ALDH1A1 (0.40) ALDH1A1KDM4EGAAKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2914664-B1 CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE DOW CORNING TORAY CO LTD (JP) 2016-09-07 EP disclosed
US-9312196-B2 Curable silicone composition, cured product thereof, and optical semiconductor DOW CORNING TORAY CO., LTD. (JP) 2016-04-12 US disclosed
US-20150252221-A1 Curable Silicone Composition, Cured Product Thereof, And Optical Semiconductor DOW TORAY CO., LTD. (JP) 2015-09-10 US disclosed
EP-2914664-A1 CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE Dow Corning Toray Co., Ltd. (JP) 2015-09-09 EP disclosed
WO-2014069610-A1 CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE DOW CORNING TORAY CO., LTD. (JP) 2014-05-08 WO disclosed
US-7932330-B2 Process for producing modified particle; carrier; catalyst component for addition polymerization; process for producing catalyst for addition polymerization; and process for producing addition polymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-04-26 US disclosed
US-7592402-B2 Process for producing modified particle; carrier; catalyst component for addition polymerization; process for producing catalyst for addition polymerization; and process for producing addition polymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-09-22 US disclosed
US-20080319148-A1 Process for producing modified particle; carrier; catalyst component for addition polymerization; process for producing catalyst for addition polymerization; and process for producing addition polymer SUMITOMO CHEMICAL COMPANY, LIMITED 2008-12-25 US disclosed
US-7115539-B2 Metal compound, and catalyst component and catalyst for addition polymerization, and process for producing addition polymer SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2006-10-03 US disclosed
US-20050245701-A1 Process for producing modified particle; carrier; catalyst component for addition polymerization; process for producing catalyst for addition polymerization; and process for producing addition polymer SUMITOMO CHEMICAL COMPANY, LIMITED 2005-11-03 US disclosed
US-20040209762-A1 Metal compound, and catalyst component and catalyst for addition polymerization, and process for producing addition polymer SUMITOMO CHEMICAL COMPANY, LIMITED 2004-10-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040209762-A1 Metal compound, and catalyst component and catalyst for addition polymerization, and process for producing addition polymer AP1M1, PYM1, SEM1 ALDH1A1 1378/4885KDM4E 1556/4885GAA 3534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.