Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.71 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.71 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.71 |
| ▸ | HNF4A | P41235 | 1/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.63 |
| ▸ | DHODH | Q02127 | 1/20 | 0.60 |
| ▸ | APP | P05067 | 7/20 | 0.58 |
| ▸ | BACE1 | P56817 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | TOP2A | P11388 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.58 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887101 | 1.00 | PTPN1 (0.71) | PTPN1PTPN2PTPN6HNF4APTGS2 | |
| SCHEMBL10892522 | 0.86 | PTPN1 (0.76) | PTPN1PTPN2PTPN6HNF4APTGS2 | |
| SCHEMBL9688131 | 0.86 | PTPN1 (0.76) | PTPN1PTPN2PTPN6HNF4APTGS2 | |
| SCHEMBL1048686 | 0.83 | PTPN1 (1.00) | PTPN1PTPN2PTPN6HNF4APTGS2 | |
| SCHEMBL6266629 | 0.83 | PTPN1 (1.00) | PTPN1PTPN2PTPN6HNF4APTGS2 | |
| SCHEMBL29938670 | 0.83 | PTPN1 (1.00) | PTPN1PTPN2PTPN6HNF4APTGS2 | |
| SCHEMBL6266631 | 0.83 | PTPN1 (1.00) | PTPN1PTPN2PTPN6HNF4APTGS2 | |
| SCHEMBL14875129 | 0.82 | PTGS2 (0.70) | PTGS2APPBACE1CYP2D6CYP2C9 | |
| SCHEMBL14875128 | 0.82 | PTGS2 (0.70) | PTGS2APPBACE1CYP2D6CYP2C9 | |
| SCHEMBL699351 | 0.82 | APP (0.71) | PTPN1PTPN2PTPN6HNF4APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9074238-B2 | Methods for enhancing neprilysin activity and degrading amyloid-beta peptides and oligomers in a subject with Alzheimer's disease | ACADEMIA SINICA (TW) | 2015-07-07 | — | — | US | disclosed |