Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.70 |
| ▸ | BACE1 | P56817 | 5/20 | 0.66 |
| ▸ | APP | P05067 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.66 |
| ▸ | MMP9 | P14780 | 3/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.66 |
| ▸ | MAOA | P21397 | 2/20 | 0.66 |
| ▸ | MAOB | P27338 | 2/20 | 0.66 |
| ▸ | TOP2A | P11388 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14875128 | 1.00 | PTGS2 (0.70) | PTGS2BACE1APPMAPTNFKB1 | |
| SCHEMBL13145953 | 0.88 | TTR (0.71) | PTGS2BACE1APPMAPTNFKB1 | |
| SCHEMBL13926061 | 0.87 | PTGS2 (0.84) | PTGS2BACE1APPMAPTNFKB1 | |
| SCHEMBL14875190 | 0.84 | L3MBTL1 (0.61) | PTGS2BACE1APPMAPTNFKB1 | |
| SCHEMBL16868833 | 0.82 | PTPN1 (0.71) | PTGS2BACE1APPMAPTNFKB1 | |
| SCHEMBL14887101 | 0.82 | PTPN1 (0.71) | PTGS2BACE1APPMAPTNFKB1 | |
| SCHEMBL25191710 | 0.81 | PTGS2 (0.62) | PTGS2NFKB1NFKB2RELAMEN1 | |
| SCHEMBL25196812 | 0.81 | PTGS2 (0.62) | PTGS2NFKB1NFKB2RELAMEN1 | |
| SCHEMBL853107 | 0.80 | PTGS2 (0.69) | PTGS2MAPTCYP2C9TSHRCA12 | |
| Curcumin SCHEMBL17629818 | 0.79 | APP (1.00) | PTGS2BACE1APPMAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130102498-A1 | COMPOSITIONS AND METHODS FOR DETECTING AMYLOID-BETA-DEGRADING ENZYME ACTIVITY | ACADEMIA SINICA (TW) | 2013-04-25 | — | — | US | disclosed |