Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.46 |
| ▸ | CHUK | O15111 | 6/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27713739 | 0.83 | IKBKB (0.52) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL3800450 | 0.82 | IKBKB (0.51) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL3792010 | 0.81 | IKBKB (0.50) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL553089 | 0.77 | IKBKB (0.46) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL552099 | 0.76 | IKBKB (0.72) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5032057 | 0.74 | IKBKB (0.34) | IKBKBCHUK | |
| SCHEMBL553190 | 0.74 | IKBKB (0.73) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL552955 | 0.74 | IKBKB (0.67) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL14391471 | 0.73 | IKBKB (0.46) | IKBKBCHUKBTKAURKAFLT3 | |
| Hydrochloric Acid SCHEMBL552987 | 0.73 | IKBKB (0.66) | IKBKBCHUKBTKAURKAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354539-B2 | Indole derivatives as IKK2 inhibitors | GLAXO GROUP LIMITED (GB) | 2013-01-15 | — | — | US | disclosed |
| US-20120010244-A1 | INDOLE DERIVATIVES AS IKK2 INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-01-12 | — | — | US | disclosed |
| US-7858796-B2 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2010-12-28 | — | — | US | disclosed |
| US-20080269291-A1 | Chemical Compounds | GLAXOSMITHKLINE LLC | 2008-10-30 | — | — | US | disclosed |
| EP-1948187-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20070254873-A1 | Chemical Compounds | GLAXO GROUP LIMITED (GB) | 2007-11-01 | — | — | US | disclosed |
| WO-2007062318-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269291-A1 | Chemical Compounds | IDO2, IKBKG, NFKBIA | IKBKB 8/4885CHUK 28/4885BTK 864/4885 |
| US-20120010244-A1 | INDOLE DERIVATIVES AS IKK2 INHIBITORS | NFKBIA, IKBKG, IDO2 | IKBKB 5/4885CHUK 7/4885BTK 539/4885 |
| US-20070254873-A1 | Chemical Compounds | IKBKG, NFKBIA, RELA | IKBKB 5/4885CHUK 9/4885BTK 386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.