Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1687386 | 1.00 | AVPR1B (0.46) | AVPR1BAVPR1A | |
| SCHEMBL1687412 | 0.92 | AVPR1B (0.47) | AVPR1B | |
| SCHEMBL1687408 | 0.92 | AVPR1B (0.47) | AVPR1B | |
| SCHEMBL1687411 | 0.91 | AVPR1B (0.49) | AVPR1B | |
| SCHEMBL1687407 | 0.91 | AVPR1B (0.49) | AVPR1B | |
| SCHEMBL3138033 | 0.86 | AVPR1B (0.57) | AVPR1BAVPR1A | |
| SCHEMBL3138040 | 0.86 | AVPR1B (0.57) | AVPR1BAVPR1A | |
| SCHEMBL1687297 | 0.86 | AVPR1B (0.55) | AVPR1B | |
| SCHEMBL1687295 | 0.86 | AVPR1B (0.55) | AVPR1B | |
| SCHEMBL1687333 | 0.85 | AVPR1B (0.56) | AVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906504-B2 | N-tert-Butyl-2-[3-(4-fluoro-3-methoxyphenyl)-1-oxo-7-(3-pyrrolidin-1-ylpropoxy)-1H-isoquinolin-2-yl]acetamide; 2-[3-(3-Chlorophenyl)-7-((S)-2-methyl-3-pyrrolidin-1-ylpropoxy)-1-oxo-1H-isoquinolin-2-yl]-N-isopropylacetamide; antidepressants; hypothalamo-pituitary-adrenal axis modulators | N.V. ORGANON (NL) | 2011-03-15 | — | — | US | disclosed |
| US-20080064678-A1 | 2-(1-OXO-1H-ISOQUINOLIN-2-YL)ACETAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064678-A1 | 2-(1-OXO-1H-ISOQUINOLIN-2-YL)ACETAMIDE DERIVATIVES | SULT2A1, ACAT2, HDAC6 | AVPR1B 1097/4885AVPR1A 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.