Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.48 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16879112 | 1.00 | PNMT (0.48) | PNMTNR1D1CLK2CLK3DYRK1A | |
| SCHEMBL16878925 | 0.84 | NR1D1 (0.46) | PNMTNR1D1LTA4H | |
| SCHEMBL16878923 | 0.84 | NR1D1 (0.46) | PNMTNR1D1LTA4H | |
| SCHEMBL14102444 | 0.82 | PNMT (0.55) | PNMTNR1D1LTA4H | |
| SCHEMBL7585285 | 0.75 | PNMT (0.61) | PNMTCLK2CLK3DYRK1A | |
| Hydrochloric Acid SCHEMBL25377106 | 0.73 | PNMT (0.59) | PNMTCLK2CLK3DYRK1A | |
| Hydrochloric Acid SCHEMBL31264082 | 0.73 | PNMT (0.59) | PNMTCLK2CLK3DYRK1A | |
| SCHEMBL5568961 | 0.73 | PNMT (0.51) | PNMT | |
| SCHEMBL5568958 | 0.73 | PNMT (0.51) | PNMT | |
| SCHEMBL14061036 | 0.72 | PNMT (0.50) | PNMTCLK2CLK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015103527-A1 | MODULATORS OF REV-ERB | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-07-09 | — | — | WO | disclosed |