Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 12/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16879424 | 0.82 | GLS (0.44) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL16879101 | 0.80 | DEGS1 (0.47) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL16887495 | 0.78 | MKNK1 (0.40) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL16879461 | 0.76 | CA1 (0.49) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL16879074 | 0.74 | GLS (0.47) | GLS | |
| SCHEMBL16887498 | 0.70 | GLS (0.58) | GLS | |
| SCHEMBL28803970 | 0.67 | GLS (0.43) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL16887488 | 0.67 | MET (0.43) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL6622747 | 0.67 | CA1 (0.60) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL17223881 | 0.67 | GLS (0.51) | CA1CA2CA5ACA7CA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092235-A2 | NOVEL INHIBITORS OF GLUTAMINASE | Rhizen Pharmaceuticals S.A. (CH) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015101958-A2 | NOVEL INHIBITORS OF GLUTAMINASE | RHIZEN PHARMACEUTICALS SA (CH) | 2015-07-09 | — | — | WO | disclosed |