Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 10/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16879516 | 0.89 | GLS (0.51) | BRAFGLSNLRP3 | |
| SCHEMBL16880045 | 0.84 | BRAF (0.48) | BRAFGLSP2RY14NTRK1NLRP3 | |
| SCHEMBL16887479 | 0.84 | BRAF (0.43) | BRAFGLSP2RY14CSNK1DNTRK1 | |
| SCHEMBL16879493 | 0.83 | GLS (0.50) | BRAFGLS | |
| SCHEMBL16879071 | 0.82 | GLS (0.43) | BRAFGLSP2RY14CSNK1DRIPK1 | |
| SCHEMBL16879484 | 0.80 | GLS (0.50) | BRAFGLSP2RY14CSNK1DNTRK1 | |
| SCHEMBL16879074 | 0.80 | GLS (0.47) | GLSP2RY14RIPK1 | |
| SCHEMBL16879453 | 0.79 | GLS (0.48) | GLSP2RY14 | |
| SCHEMBL16887481 | 0.77 | GLS (0.52) | BRAFGLS | |
| SCHEMBL16887474 | 0.75 | BRAF (0.48) | BRAFGLSP2RY14NTRK1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092235-A2 | NOVEL INHIBITORS OF GLUTAMINASE | Rhizen Pharmaceuticals S.A. (CH) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015101958-A2 | NOVEL INHIBITORS OF GLUTAMINASE | RHIZEN PHARMACEUTICALS SA (CH) | 2015-07-09 | — | — | WO | disclosed |