Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.67 |
| ▸ | ACVR1B | P36896 | 18/20 | 0.67 |
| ▸ | ACVRL1 | P37023 | 15/20 | 0.67 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.60 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16879398 | 0.83 | TGFBR1 (0.76) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879670 | 0.83 | TGFBR1 (0.76) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879552 | 0.83 | TGFBR1 (0.57) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879273 | 0.80 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL16888494 | 0.75 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879640 | 0.75 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879680 | 0.74 | TGFBR1 (0.81) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL22270342 | 0.73 | TGFBR1 (0.81) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879186 | 0.73 | TGFBR1 (0.72) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16888478 | 0.73 | TGFBR1 (0.76) | TGFBR1ACVR1BACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3089971-A1 | COMPOUNDS AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2016-11-09 | — | — | EP | disclosed |
| WO-2015103355-A1 | COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-07-09 | — | — | WO | disclosed |