Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.34 |
| ▸ | STS | P08842 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16879876 | 0.82 | CYP19A1 (0.55) | CYP19A1STS | |
| SCHEMBL16879760 | 0.81 | CYP19A1 (0.37) | HSD17B10SMN1; SMN2PPARGALDH1A1CYP19A1 | |
| SCHEMBL16879878 | 0.80 | NPSR1 (0.38) | CNR1CNR2KDM4ENPSR1TSHR | |
| SCHEMBL16879722 | 0.69 | GABRA1 (0.32) | HSD17B10ALDH1A1CYP19A1STSHPGD | |
| SCHEMBL2494278 | 0.68 | SLC9A1 (0.41) | KDM4ENPSR1TSHRSMN1; SMN2POLB | |
| SCHEMBL16879754 | 0.65 | CYP11B1 (0.51) | NPSR1TSHRLMNASMN1; SMN2PPARG | |
| SCHEMBL16879688 | 0.65 | CYP19A1 (0.59) | CYP19A1STS | |
| SCHEMBL7813049 | 0.65 | KMT2A (0.56) | KDM4ENPSR1SMN1; SMN2POLBKMT2A | |
| SCHEMBL31130802 | 0.64 | SLC9A1 (0.55) | KDM4ENPSR1POLBKMT2AALDH1A1 | |
| SCHEMBL28863784 | 0.64 | SLC9A1 (0.55) | KDM4ENPSR1POLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3089966-A1 | NEW SUBSTITUTED BIPHENYL ANALOGUES AS DUAL INHIBITORS OF AROMATASE AND SULFATASE | Beaufour Ipsen Tianjin Pharmaceutical Co., Ltd (CN) | 2016-11-09 | — | — | EP | disclosed |
| WO-2015100609-A1 | NEW SUBSTITUTED BIPHENYL ANALOGUES AS DUAL INHIBITORS OF AROMATASE AND SULFATASE | BEAUFOUR IPSEN TIANJIN PHARMACEUTICAL CO., LTD (CN) | 2015-07-09 | — | — | WO | disclosed |