Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.34 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.34 |
| ▸ | RRM1 | P23921 | 1/20 | 0.33 |
| ▸ | RRM2 | P31350 | 1/20 | 0.33 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13185094 | 0.84 | — | — | |
| SCHEMBL5489086 | 0.79 | CA2 (0.42) | FOLH1NAALAD2RIMKLASMN1; SMN2 | |
| SCHEMBL4519259 | 0.79 | CA2 (0.42) | FOLH1NAALAD2RIMKLASMN1; SMN2 | |
| SCHEMBL11131045 | 0.79 | CA2 (0.42) | FOLH1NAALAD2RIMKLASMN1; SMN2 | |
| SCHEMBL1632238 | 0.78 | ECE1 (0.33) | FOLH1NAALAD2RRM1RRM2RRM2B | |
| SCHEMBL10272243 | 0.77 | MAPT (0.41) | FOLH1NAALAD2LMNAMAPT | |
| SCHEMBL11298062 | 0.77 | MAPT (0.39) | FOLH1NAALAD2ALDH1A1MEN1LMNA | |
| Ammonia Solution, Strong SCHEMBL4950520 | 0.77 | TDP1 (0.44) | FOLH1NAALAD2RIMKLASMN1; SMN2 | |
| SCHEMBL16675994 | 0.76 | MAPT (0.53) | FOLH1NAALAD2RRM1RRM2RRM2B | |
| SCHEMBL25928849 | 0.76 | ACE (0.36) | FOLH1NAALAD2RRM1RRM2RRM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120283411-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-11-08 | — | — | US | disclosed |
| US-20120088902-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088902-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | GRPR, GCGR, GIPR | FOLH1 2980/4885NAALAD2 3937/4885RRM1 3059/4885 |
| US-20120283411-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | GRPR, GCGR, GIPR | FOLH1 2980/4885NAALAD2 3937/4885RRM1 3059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.