Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 13/20 | 0.43 |
| ▸ | KLK1 | P06870 | 13/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16880811 | 0.88 | ATM (0.42) | CYP11B1CYP11B2KLKB1KLK1NPSR1 | |
| SCHEMBL16881310 | 0.86 | KMT2A (0.60) | KMT2ACYP11B1CYP11B2KLKB1KLK1 | |
| SCHEMBL16881056 | 0.79 | KDM4E (0.50) | KMT2ACYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL28105209 | 0.78 | KMT2A (0.60) | KMT2AKDM4EALDH1A1HCAR2NPC1 | |
| SCHEMBL12252468 | 0.77 | KMT2A (0.57) | KMT2AALDH1A1NPSR1HCAR2MAPT | |
| SCHEMBL16881016 | 0.77 | KLKB1 (0.49) | KLKB1KLK1 | |
| SCHEMBL16881038 | 0.76 | KMT2A (0.42) | KMT2AKLKB1KLK1KDM4EALDH1A1 | |
| SCHEMBL16881452 | 0.76 | KLKB1 (0.47) | KLKB1KLK1 | |
| SCHEMBL16881357 | 0.76 | KMT2A (0.43) | KMT2AKLKB1KLK1KDM4EALDH1A1 | |
| SCHEMBL16891565 | 0.74 | KMT2A (0.48) | KMT2ACYP11B2KLKB1KLK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061480-B | Therapeutic inhibitory compounds | 莱福斯希医药公司 | 2020-02-28 | — | — | CN | disclosed |
| EP-3089746-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | Lifesci Pharmaceuticals, Inc. (BB) | 2016-11-09 | — | — | EP | disclosed |
| CN-106061480-A | Therapeutic inhibitory compounds | 莱福斯希医药公司 | 2016-10-26 | — | — | CN | disclosed |
| WO-2015103317-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | LIFESCI PHARMACEUTICALS, INC. (BB) | 2015-07-09 | — | — | WO | disclosed |