Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743884 | 0.89 | SIGMAR1 (0.54) | SIGMAR1OPRM1OPRK1KCNH2 | |
| SCHEMBL15158598 | 0.88 | SIGMAR1 (0.53) | SIGMAR1OPRM1OPRK1KCNH2 | |
| SCHEMBL15160120 | 0.83 | SIGMAR1 (0.72) | SIGMAR1 | |
| SCHEMBL4206840 | 0.76 | SIGMAR1 (0.80) | SIGMAR1 | |
| SCHEMBL8014953 | 0.76 | SIGMAR1 (0.63) | SIGMAR1OPRM1OPRK1KCNH2 | |
| SCHEMBL17367289 | 0.75 | SIGMAR1 (0.57) | SIGMAR1OPRM1OPRK1KCNH2 | |
| SCHEMBL8010724 | 0.75 | SIGMAR1 (0.66) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL2882074 | 0.75 | SIGMAR1 (0.78) | SIGMAR1 | |
| SCHEMBL13519328 | 0.75 | SIGMAR1 (0.59) | SIGMAR1OPRM1OPRK1KCNH2 | |
| SCHEMBL15160318 | 0.74 | FFAR1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150266839-A1 | CYCLIC AMIDE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2015-09-24 | — | — | US | disclosed |
| US-9072758-B2 | Cyclic amide derivative | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2015-07-07 | — | — | US | disclosed |
| US-20140057871-A1 | CYCLIC AMIDE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2014-02-27 | — | — | US | disclosed |
| US-20130203739-A1 | CYCLIC AMIDE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2013-08-08 | — | — | US | disclosed |
| WO-2012046869-A1 | CYCLIC AMIDE DERIVATIVE | 持田製薬株式会社 (JP) | 2012-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266839-A1 | CYCLIC AMIDE DERIVATIVE | GPR119, NR0B1, NR4A1 | SIGMAR1 484/4885OPRM1 1421/4885OPRK1 1109/4885 |
| US-20140057871-A1 | CYCLIC AMIDE DERIVATIVE | GPR119, NR0B1, NR4A1 | SIGMAR1 474/4885OPRM1 1383/4885OPRK1 1161/4885 |
| US-20130203739-A1 | CYCLIC AMIDE DERIVATIVE | GPR119, NR0B1, NR2C2 | SIGMAR1 250/4885OPRM1 824/4885OPRK1 650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.