Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.91 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.91 |
| ▸ | LRAT | O95237 | 2/20 | 0.88 |
| ▸ | MEN1 | O00255 | 2/20 | 0.88 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.88 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | RECQL | P46063 | 1/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | GJA1 | P17302 | 1/20 | 0.72 |
| ▸ | GJB2 | P29033 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ribostamycin SCHEMBL48820 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 | |
| Ribostamycin SCHEMBL13599669 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 | |
| Ribostamycin SCHEMBL19944115 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 | |
| Ribostamycin SCHEMBL13605470 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 | |
| Ribostamycin SCHEMBL15432715 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 | |
| SCHEMBL19619289 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 | |
| SCHEMBL19619262 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 | |
| SCHEMBL17321247 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 | |
| Ribostamycin SCHEMBL20530016 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 | |
| Ribostamycin SCHEMBL48819 | 1.00 | LMNA (1.00) | LMNATSHRHSD17B10LRATMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073958-B2 | Aminoglycosides and uses thereof in the treatment of genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2015-07-07 | — | — | US | disclosed |