Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE6D | O43924 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16666271 | 0.85 | KDM4E (0.39) | PDE5AADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL16885077 | 0.84 | GUSB (0.46) | PDE5AKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL15426464 | 0.83 | ALOX5AP (0.43) | PDE5AADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL16885115 | 0.82 | PDE5A (0.44) | PDE5AADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL16885124 | 0.74 | NPC1 (0.36) | ADORA3ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL16666988 | 0.73 | L3MBTL1 (0.48) | KDM4EALDH1A1SMN1; SMN2GUSBMEN1 | |
| SCHEMBL16885104 | 0.72 | ALOX5AP (0.36) | ADORA3ADORA2AADORA1ALDH1A1NPC1 | |
| SCHEMBL16885128 | 0.72 | NPC1 (0.42) | ADORA3ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL16885092 | 0.70 | MAPT (0.49) | ALDH1A1NPC1GUSBMEN1LMNA | |
| SCHEMBL10739495 | 0.70 | NPC1 (0.49) | PDE5AADORA3ADORA2AADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328121-B1 | Fused heterocyclic compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-05-03 | — | — | US | disclosed |
| US-20160102100-A1 | FUSED HETEROCYCLIC COMPOUND | SUMITOMO CHEMICAL CO (JP) | 2016-04-14 | — | — | US | disclosed |
| US-9260436-B2 | Fused heterocyclic compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-02-16 | — | — | US | disclosed |
| US-20150191474-A1 | FUSED HETEROCYCLIC COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102100-A1 | FUSED HETEROCYCLIC COMPOUND | NR4A1, CYP4B1, NR1H4 | PDE5A 3903/4885ADORA3 565/4885ADORA2A 805/4885 |
| US-20150191474-A1 | FUSED HETEROCYCLIC COMPOUND | NR4A1, NR0B1, NR0B2 | PDE5A 3907/4885ADORA3 807/4885ADORA2A 1556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.