Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.34 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688578 | 0.85 | PLK1 (0.31) | PLK1PLK3PLK2 | |
| SCHEMBL1688486 | 0.84 | PLK2 (0.42) | PLK1PLK3PLK2 | |
| SCHEMBL1688607 | 0.83 | PLK2 (0.37) | PLK1PLK3PLK2 | |
| SCHEMBL1688600 | 0.81 | PLK2 (0.50) | PLK1PLK3PLK2 | |
| SCHEMBL10286980 | 0.77 | PLK2 (0.35) | PLK1PLK3PLK2 | |
| SCHEMBL1688619 | 0.77 | PLK2 (0.41) | PLK1PLK3PLK2 | |
| SCHEMBL2689464 | 0.75 | PDE2A (0.37) | — | |
| SCHEMBL1688434 | 0.74 | OGG1 (0.35) | — | |
| SCHEMBL1288576 | 0.74 | OGG1 (0.35) | — | |
| SCHEMBL2691935 | 0.74 | PLK1 (0.32) | PLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048129-A2 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |