Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK2 | Q9NYY3 | 16/20 | 0.37 |
| ▸ | PLK1 | P53350 | 13/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688486 | 0.88 | PLK2 (0.42) | PLK2PLK1PLK3 | |
| SCHEMBL1688600 | 0.85 | PLK2 (0.50) | PLK2PLK1PLK3 | |
| SCHEMBL1688574 | 0.83 | PLK1 (0.34) | PLK2PLK1PLK3 | |
| SCHEMBL1688619 | 0.82 | PLK2 (0.41) | PLK2PLK1PLK3 | |
| SCHEMBL2687968 | 0.80 | PLK1 (0.53) | PLK2PLK1PLK3 | |
| SCHEMBL2687966 | 0.80 | PLK1 (0.53) | PLK2PLK1PLK3 | |
| SCHEMBL10286980 | 0.79 | PLK2 (0.35) | PLK2PLK1PLK3ALDH1A1KMT2A | |
| SCHEMBL1688434 | 0.78 | OGG1 (0.35) | MAPTTSHR | |
| SCHEMBL1288576 | 0.78 | OGG1 (0.35) | MAPTTSHR | |
| SCHEMBL2689464 | 0.77 | PDE2A (0.37) | ALDH1A1KMT2AKDM4EALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048129-A2 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |