Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688616 | 0.82 | MAPT (0.42) | ALDH1A1AVPR1AMAPTLMNAMAPK1 | |
| SCHEMBL1688496 | 0.81 | PLK1 (0.37) | ALDH1A1AVPR1AMAPTLMNAMAPK1 | |
| SCHEMBL1288635 | 0.79 | PLK1 (0.46) | BRD4 | |
| SCHEMBL1288631 | 0.79 | PLK1 (0.46) | BRD4 | |
| SCHEMBL2689464 | 0.76 | PDE2A (0.37) | PIK3CGALDH1A1AVPR1AMAPTUSP2 | |
| SCHEMBL2689918 | 0.73 | PDE2A (0.38) | PIK3CGALDH1A1AVPR1AMAPTALOX15 | |
| SCHEMBL1688486 | 0.72 | PLK2 (0.42) | — | |
| SCHEMBL2689540 | 0.72 | PDE2A (0.37) | ALDH1A1AVPR1AMAPTALOX15BRD4 | |
| SCHEMBL1688434 | 0.71 | OGG1 (0.35) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10286248 | 0.71 | MTOR (0.39) | AVPR1ALMNAPIK3CAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048129-A2 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |