Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 19/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16888778 | 1.00 | CCR5 (1.00) | CCR5KCNH2CYP2D6CYP3A4 | |
| SCHEMBL18203691 | 0.90 | CCR5 (1.00) | CCR5KCNH2CYP2D6CYP3A4 | |
| SCHEMBL18203720 | 0.89 | CCR5 (1.00) | CCR5KCNH2CYP2D6CYP3A4 | |
| SCHEMBL20448859 | 0.89 | CCR5 (1.00) | CCR5KCNH2CYP2D6CYP3A4 | |
| SCHEMBL18511284 | 0.88 | CCR5 (0.79) | CCR5KCNH2CYP2D6CYP3A4 | |
| SCHEMBL18203722 | 0.87 | CCR5 (1.00) | CCR5KCNH2CYP2D6CYP3A4 | |
| SCHEMBL18511326 | 0.87 | CCR5 (0.85) | CCR5KCNH2CYP2D6CYP3A4 | |
| SCHEMBL16888757 | 0.87 | CCR5 (1.00) | CCR5KCNH2CYP2D6CYP3A4 | |
| SCHEMBL18203690 | 0.87 | CCR5 (1.00) | CCR5KCNH2CYP2D6CYP3A4 | |
| SCHEMBL18203598 | 0.87 | CCR5 (1.00) | CCR5KCNH2CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10167299-B2 | 1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-01-01 | — | — | US | disclosed |
| US-10167299-B2 | 1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-01-01 | — | — | US | disclosed |
| EP-3091013-B1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2018-08-08 | — | — | EP | disclosed |
| US-20170044187-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-02-16 | — | — | US | disclosed |
| US-20170044187-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-02-16 | — | — | US | disclosed |
| US-20170044187-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-02-16 | — | — | US | disclosed |
| EP-3091013-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2016-11-09 | — | — | EP | disclosed |
| EP-3091013-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2016-11-09 | — | — | EP | disclosed |
| WO-2015101265-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | 中国科学院上海药物研究所 | 2015-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044187-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | CCR5, CCR1, CCRL2 | CCR5 1/4885KCNH2 3387/4885CYP2D6 719/4885 |
| US-10167299-B2 | 1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof | CCR5, CCRL2, CCR1 | CCR5 1/4885KCNH2 3749/4885CYP2D6 1196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.