Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A2 | O94788 | 3/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688956 | 0.93 | ALDH1A1 (0.43) | DHFRALDH1A1GAALMNAMEN1 | |
| SCHEMBL1689197 | 0.87 | ALDH1A1 (0.49) | DHFRALDH1A1GAALMNAMEN1 | |
| SCHEMBL1689073 | 0.87 | TP53 (0.51) | DHFRALDH1A1GAALMNAMEN1 | |
| SCHEMBL5611868 | 0.87 | ALDH1A1 (0.51) | DHFRALDH1A1GAALMNAMEN1 | |
| SCHEMBL1689360 | 0.85 | TP53 (0.41) | DHFRALDH1A1GAALMNAMEN1 | |
| SCHEMBL5611994 | 0.85 | MAPT (0.49) | DHFRALDH1A1GAALMNAMEN1 | |
| SCHEMBL1689299 | 0.85 | CYP1A2 (0.41) | DHFRALDH1A1GAALMNAMEN1 | |
| SCHEMBL1689442 | 0.84 | TP53 (0.40) | DHFRALDH1A1GAALMNAMEN1 | |
| SCHEMBL5611832 | 0.83 | MAPT (0.50) | DHFRALDH1A1GAALMNAMEN1 | |
| SCHEMBL5611720 | 0.81 | TRPV4 (0.42) | DHFRALDH1A1GAALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | claimed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | claimed |
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | disclosed |